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Latest research from the American Academy of Ophthalmology

Large-Scale Databases in Ophthalmic Research: Caveat Lector

The concept of analyzing a large preexisting database to answer important clinical questions is attractive because of the impracticality, time, and financial costs of conducting a randomized clinical trial (RCT) and the limited generalizability of small retrospective or prospective studies performed at 1 or several…

Henry Jampel, Nur CardakliRead

Ophthalmology· Article

This Issue at a Glance

In this population-based retrospective study of IRIS® Registry (Intelligent Research in Sight) data, Ashourizadeh et al (p. xxx) evaluated the association between cataract surgery (CS) and the risk of conversion from dry age-related macular degeneration (dAMD) to neovascular AMD (nvAMD). Analysis of 40 053 eyes…

Oct 12, 2026 · Sandeep Ravindran

Retina· Pictures & Perspectives

Spontaneous Regression of Subretinal Fluid in Advanced Coats’ Disease

A 2-year-old boy presented with esotropia for 9 months. Examination was unremarkable in the right eye and revealed retrolental total exudative retinal detachment in the left eye (A and B). B-scan ultrasonography showed no calcifications or mass lesions, and magnetic resonance imaging was normal, excluding…

Oct 12, 2026 · Waleed Khayyat, Sulaiman AlSulaiman

Glaucoma· Manuscript

Scleral-Tunneled, Graft-Free Glaucoma Drainage Device Implantation in Children: Outcomes from a US Tertiary Center

To report IOP outcomes, medication use, tube exposure rates, and surgical durability following ST-GDD in children.

Oct 12, 2026 · Musse Hussein, Ziou Jiang et al.

Glaucoma· Manuscript

Glaucoma Severity and Progression in Individuals with Asymmetric β-zone Parapapillary Atrophy: An Intra-patient Comparative Study

To investigate inter-eye differences in glaucoma severity and progression in patients with asymmetric baseline β-zone parapapillary atrophy (PPA) morphology.

Oct 12, 2026 · Se Hie Park, Sung Do Cho et al.

Glaucoma· Manuscript

Comparative Outcomes of Stent vs. Non-Stent Trabecular Minimally Invasive Glaucoma Surgeries: A 4-Year Retrospective Propensity-Matched Study

To compare 48-month outcomes of stent-based versus non-stent trabecular minimally invasive glaucoma surgery (MIGS) performed with phacoemulsification in open-angle glaucoma.

Oct 12, 2026 · Muhammad Abrar Irfan, Juliet Johnson et al.

Science· Article

Central Visual Field Differences Between Monocular and Binocular Random Perimetry in Glaucoma

To characterize differences between monocular testing and binocular random testing and determine whether they vary by eccentricity and better/worse eye role.

Oct 12, 2026 · Takuhei Shoji, Takahiro Kuraishi et al.

Science· Article

A Digital Early-Warning Score for Uveitis Flare: Development and Initial Validation

Uveitis flares are unpredictable events that may cause irreversible visual loss when detection is delayed.1 Patients are evaluated at fixed intervals, leaving a window during which flares may go unrecognized, and no validated patient-reported outcome (PRO) instrument exists for flare detection between scheduled…

Oct 12, 2026 · Francesco Pichi, Vika Egorov et al.

Science· Article

Cell Density Mapped Retinal Nonperfusion and Low-Luminance Visual Acuity in Diabetic Retinopathy

To determine whether cell density–weighted retinal nonperfusion, derived by mapping ultra-widefield fluorescein angiography (UWF-FA)–defined nonperfusion to rod, cone, and retinal ganglion cell topography, is associated with low-luminance visual acuity (LLVA) in eyes with diabetic retinopathy (DR) and provides…

Oct 12, 2026 · Kallista Zhuang, Shinji Kakihara et al.

Science· Article

Patterns and Predictors of Misclassifications by Large Language Models in Multimodal Glaucoma Diagnosis

To assess patterns and predictors of misclassification by multimodal large language models (LLMs) GPT-5 Pro and Gemini 3 Pro in glaucoma diagnosis.

Oct 12, 2026 · Tathya V. Shah, Ryan S. Shean et al.

Ophthalmology· Correspondence

RE: Cheng et al: A new intraocular lens power calculation formula for eyes undergoing lens exchange (Ophthalmology. 2026;133:700–708)

We read with great interest the article by Cheng et al1 describing the novel manifest refraction (MR) biometry formula for intraocular lens (IOLs) power calculation in eyes undergoing IOL exchange. The authors should be commended for addressing a challenging clinical scenario. However, we would appreciate clarification…

Oct 10, 2026 · Christian Sabatiello, Pasquale Alfano

Ophthalmology· Article

Assessment of the Necessity for High-Level Disinfection (HLD) of Reusable Ophthalmic Devices: A Multisociety Position Paper

Regulatory agencies in the United States and abroad are increasingly citing clinics and surgical facilities for what they deem to be inadequate disinfection of Goldmann applanation tonometry (GAT) tips, gonioscopy lenses, laser lenses, and other reusable clinic devices that contact the ocular surface. These regulators…

Oct 9, 2026 · Irene C. Kuo, David F. Chang et al.

Ophthalmology· Article

Prevalence of Diabetic Retinopathy and Cardiovascular Risk Factors Among Diverse Hispanic/Latino Adults: HCHS/SOL and SOL Ojos Results.

To estimate diabetic retinopathy (DR) prevalence among Hispanic/Latino adults with diabetes, assess heterogeneity by background group, and evaluate cardiovascular disease (CVD) risk factors.

Oct 9, 2026 · Lawrence J. Ulanski, Angie Wang et al.

Ophthalmology· Correspondence

REPLY:

We thank Dr Zhang et al for their interest in our study1 and for raising 2 clinically relevant points that merit future exploration.

Oct 9, 2026 · Jian Zhao, Anquan Xue et al.

Ophthalmology· Correspondence

Re: Zhao et al.: Incidence and Associated Factors of Myopic Maculopathy Progression After Posterior Scleral Contraction in High Myopia (Ophthalmology. 2026;133:506–514)

We read with great interest the recent article by Zhao et al1 and would like to raise 2 points we believe merit further discussion.

Oct 9, 2026 · Yan Zhang, Zheng Zhang et al.

Glaucoma· Pictures & Perspectives

Same-Eye Multimodal Correlation of Adaptive Optics Imaging of the Trabecular Meshwork

Panel A is a normal-eye adaptive optics (AO) reference, not part of the same-eye correlation. In the index glaucoma eye, preoperative AO showed a beam- and pore-like trabecular meshwork (TM) network (B). Postoperative AO identified the iStent in the same angle region (C). Anterior-segment OCT–supported localization…

Oct 9, 2026 · Shigeru Mori

Ophthalmology· Correspondence

Re: MacKinnon et al.: Prevalence of Strabismus and Decreased Stereopsis in Parents of Children with Strabismus (Ophthalmology. 2026;133:1099–1107)

MacKinnon et al1 report a high prevalence of abnormal sensorimotor findings among parents of children with strabismus and propose reduced stereopsis as a potential endophenotype for future genetic studies. Although familial enrichment of impaired stereopsis is intriguing, 2 aspects of the study warrant consideration…

Oct 8, 2026 · Vignesh Lakshmanan

Ophthalmology· Pictures & Perspectives

Red Alert: A New Presentation of Intraocular Lens Discoloration

A 77-year-old woman had silicone plate intraocular lenses (IOLs) implanted bilaterally in 2003. Asymptomatic IOL discoloration was noted in both eyes on routine examination in 2023. A dramatic scarlet red hue was seen in the outer third of the IOL material, more pronounced in the posterior and peripheral regions than…

Oct 8, 2026 · Malik S. Ladki, Stephen M. Hamilton et al.

Retina· Pictures & Perspectives

Vertical Hyperreflective Columns in Ocular Sarcoidosis

A man in his 60s with a biopsy-proven diagnosis of sarcoidosis presented with bilateral panuveitis. Right-eye (A) initial fundus photography showed mild vitritis, a macular pseudohole, and perivascular whitish infiltrates. Two years after systemic and intravitreal corticosteroid treatment, vitritis had resolved, and…

Oct 8, 2026 · Inês Mendo, Diogo Cabral et al.

Retina· Commentary

Statins and Age-Related Macular Degeneration

Pivotal trials of drugs used for systemic disease are generally designed around systemic outcomes, leaving potential ocular effects poorly characterized. Statins and age-related macular degeneration (AMD) illustrate this evidence gap. The accumulation of lipids in the Bruch membrane and drusen provides biological…

Oct 8, 2026 · Xiaodong Chen, Ya Xing Wang

Retina· Editorial

A Solution in Search of Evidence: Yttrium–Aluminum–Garnet Vitreolysis for Vitreous Floaters

Vitreous floaters occupy a curious space in clinical ophthalmology: exceedingly common, often dismissed, yet capable of inflicting genuine visual disability in certain individuals. Resulting from vitreous liquefaction and fibrous degeneration associated with aging and myopia, vitreous floaters are closely linked to…

Oct 8, 2026 · Rahul N. Khurana

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Latest research from the American Academy of Ophthalmology